It has been known for 20 years that the ribosomal protein S6 is rapidly phosphorylated when cells are stimulated to grow or divide. Furthermore, numerous studies have documented that there is a strong correlation between increases in S6 phosphorylation and protein synthesis, leading to the idea that S6 phosphorylation is involved in up‐regulating translation. In an attempt to define a mechanism by which S6 phosphorylation exerts translational control, other studies have focused on characterizing the sites of phosphorylation of this protein (...) and its location within the ribosome. Recent data show that S6 is a protein which may have diverse cellular functions and is essential for normal development, and that it may be involved in the translational regulation of a specific class of messages. (shrink)

This 1997 book was the first English translation of all of Kant's writings on moral and political philosophy collected in a single volume. No other collection competes with the comprehensiveness of this one. As well as Kant's most famous moral and political writings, the Groundwork of the Metaphysics of Morals, the Critique of Practical Reason, the Metaphysics of Morals, and Toward Perpetual Peace, the volume includes shorter essays and reviews, some of which have never been translated before. The volume has (...) been furnished with a substantial editorial apparatus including translator's introductions and explanatory notes to each text by Mary Gregor, and a general introduction to Kant's moral and political philosophy by Allen Wood. There is also an English-German and German-English glossary of key terms. (shrink)

The Metaphysics of Morals is Kant's major work in applied moral philosophy in which he deals with the basic principles of rights and of virtues. It comprises two parts: the 'Doctrine of Right', which deals with the rights which people have or can acquire, and the 'Doctrine of Virtue', which deals with the virtues they ought to acquire. Mary Gregor's translation, revised for publication in the Cambridge Texts in the History of Philosophy series, is the only complete translation of the (...) whole text, and includes extensive annotation on Kant's difficult and sometimes unfamiliar vocabulary. A new introduction by Roger Sullivan sets the work in its historical and philosophical context. This volume will be of wide interest to students of ethics and of legal and political philosophy. (shrink)

The Critique of Practical Reason is the second of Kant's three Critiques, one of his three major treatises on moral theory, and a seminal text in the history of moral philosophy. Originally published three years after his Groundwork to the Metaphysics of Morals, the Critique provides further elaboration of the basic themes of Kant's moral theory, gives the most complete statement of his highly original theory of freedom of the will, and develops his practical metaphysics. This new edition of Kant's (...) Critique of Practical Reason – prepared by an acclaimed translator and scholar of Kant's practical philosophy – presents the first new translation of this work to appear for some years. A substantial and lucid introduction by Andrews Reath places the main themes of the Critique in the context of Kant's moral theory and his critical system. (shrink)

In the wake of important scholarship on Jesus’ humanity, feminist chris-tology suffers from a struggle to articulate the divinity of Jesus Christ because of its criticism of sacrificial atonement theory, which has led to didactic or exemplary models of redemption. Feminist theology stands in need of further discussion in an effort to articulate feminist incarnational atonement theory more thoroughly. Schleiermacher’s theology, especially as it is articulated in his theory of preaching, aids feminist theology in claiming Jesus’ divinity while simultaneously maintaining (...) criticism of a violent atonement and relocating the power of the incarnation away from Jesus’ maleness to the preached Word in the community. The basis of feminist incarnational atonement theory is initially found within four major areas of dialogue: in a central focus on Jesus’ life, in definitions of redemption, in the centrality of community, and in criticism of the violence of the atonement. (shrink)

Language for God explores the ways language and images influence who we are and how we live. It declares the necessity of language and images for God that are expansive and inclusive of all genders. Lutheran perspectives are used as a compass to offer scriptural, theological, and historical insights to advance the reformation of Christian language.

In a time of rapid technological and social change, business organizations must help their employees develop a new appreciation of how social and ethical values are being shaped and challenged by evolving information technologies. Many ethical and social conflicts have arisen around the advanced information technology used today. The emerging technologies continue to create situations not previously encountered. There are numerous risks facing corporations involved in the use of computing technology. Leaders of organizations looking ahead to assess the impact of (...) technological changes can try to prepare their employees for the future. This paper addresses the urgent need for individuals in corporations to become more knowledgeable about computing technologies and their impact. (shrink)

A Treatise of Human Nature, David Hume's comprehensive attempt to base philosophy on a new, observationally grounded study of human nature, is one of the most important texts in Western philosophy. It is also the focal point of current attempts to understand 18th-century western philosophy. The Treatise addresses many of the most fundamental philosophical issues: causation, existence, freedom and necessity, and morality. The volume also includes Humes own abstract of the Treatise, a substantial introduction, extensive annotations, a glossary, a comprehensive (...) index, and suggestions for further reading. (shrink)

This issue of Business & Society contains the transcripts of 12 oral history interviews with founders of and early contributors to the business and society/social issues in management field. The publication of these interviews is the culmination of a very long-term project, with the first interview having been conducted in 1993 with Lee Preston and the most recent interview having been conducted in 2011 with Jim Post. This project has been very much of a team effort with Sandra Waddock, John (...) Steiner, Mary Mallott, Ariane Berthoin Antal, and, of course, our interviewees all playing important roles. (shrink)

Conspicuous in the Old Testament is the literary genre of blessing that is often construed in poetic forms. They are of various types and were significant to their initial audience. A careful analysis of their texts and contexts is indispensable for a correct understanding of their message. Conversely, in our times, these texts and their contents are misinterpreted for some subjective goals, which deviate greatly from what one can perceive as their original meaning and intention. Misinterpretation and incorrect application of (...) Biblical texts of blessings thrive in a society like ours where ills are perpetrated under the guise of religion. The text of Genesis 27:27–29, carefully inserted in the patriarchal narratives, contains a type of OT blessings portraying parents’ wishful desires for their offspring; this is common to all human cultures. It is chosen as a springboard for the study of other parental blessings in the OT. Employing a literary analysis with particular attention to the functions of poetic devices in the text, the study aimed at understanding the message contained therein and its relevance to our contemporary society. (shrink)

The church shares in Christ’s mission of bringing all to the knowledge of God and to salvation. All its members are called to this intrinsic mission bequeathed to the entire church. The lay faithful form the greatest number of the members and their functions are important in this mission. However, they are beset by numerous setbacks that constitute untold challenges for the church. This article, written from a sub-Saharan African and Catholic background, examines the nature of this mission as a (...) requisite prelude to discussion on various challenges experienced by the laity in participating fully in the mission. It also recommends ways of enhancing their contributions.Contribution: The primary contribution of this article is its specific focus on the challenges the laity encounter in carrying out their mission in the world. It is a theological study based on scriptural foundations of the laity in the church. As members, laypersons share fully in the church’s received mission mandate. (shrink)

David and Mary Norton present the definitive scholarly edition of Hume's Treatise, one of the greatest philosophical works ever written. This set comprises the two volumes of texts and editorial material, which are also available for purchase separately.

Since the theme of this issue is ‘back to the future,’ especially to the ways in which information formats before the age of printing anticipate and perhaps even may give some guidance to principles of organization and cognitive layouts for the ‘new’ science of information design, I am going to focus in my presentation on the design of memory storage, as it was taught and practiced in the Middle Ages. It is important to recognize that ‘memory-art’ accompanied every aspect of (...) education in the ancient trivium, though different aspects and capacities of human memory were emphasized as appropriate to its various disciplines. What is commonly now taken to be ‘the art of memory,’ namely the advice to link powerful images of ‘content’ (imagines rerum) together in dramatic scenes conceived within a mental location (locus) (as described most completely in the early first century B.C. Rhetorica ad Herennium) is not a universal technique but specifically a device of Rhetoric, and thus of composition. There is also an ‘art of memory’ associated with Dialectic, and this is the device of the ‘topics’ or ‘seats’ (topoi) of argument, syllogism and enthymeme arranged in an orderly schematic of specific mental ‘places.’ Aristotle expounded this scheme as a variety of mnemonic art in his treatise Peri Topoi, and in turn it was further disseminated to later antiquity and the Middle Ages in works by Cicero and Boethius. (shrink)

In A Rhetoric and Philosophy of Gifts, Eberhardinger discusses how gift character is one of the only qualities that individuate us as social beings on Earth. The horizon and rhetorical power of gift character offers discursive revelations about communication and the human condition.

This essay explores the implications of a commonly held ancient and medieval belief that human memory and invention are, if not exactly the same, the closest thing to it. In order to create, in order to think at all, human beings require both a well-provisioned stock of memory-held knowledge and some mental tool or machine, an engine which lives in the intricate networks of their own memories. In the verbal arts of the trivium students learned the basic principles of memory (...) training: the need for divisio, the need to make a clear, distinct location for each piece of memorized content, and the need to mark items uniquely for secure recollection. Frequently these mental structures took the form of images. Evidence for such memorial and compositional images is common: I focus on a few representative types, including the sermon-related “Cherub” figure of the later Middle Ages, and accounts by Cassiodorus and others of scholars, even when blind, using their highly structured memories to compose new work. (shrink)

In this essay, the structure and content of theiones, a mid-thirteenthcentury collection of sophismata ascribed to a ‘Magister Ricardus’, are described. It is then argued that the text of the Abstractiones itself together with its “descendant” works present us with a case of textual evolution: the main text appears itself to be the result of patchwork and development, with each manuscript in effect a variation of the work; the descendant works continue the job of modifying the text, now so selectively (...) and radically that they can no longer be described as versions of the Abstractiones itself. (shrink)

ALTHOUGH the content of Alexander Gottlieb Baumgarten's Aesthetica seems to be familiar in German philosophical circles, it is relatively unknown outside Germany. Most of us are aware that it was Baumgarten who coined the name "aesthetics" for the new philosophical discipline his Aesthetica was intended to establish; but as for the content of that work, our acquaintance is likely to be indirect, through two remarks of Kant. Explaining his own use of "Transcendental Aesthetic" in the Critique of Pure Reason, Kant (...) criticizes Baumgarten's "abortive attempt... to bring the critical treatment of the beautiful under rational principles and so to raise its rules to the rank of a science". In the Critique of Judgment, it is generally assumed to be Baumgarten Kant has in mind when, arguing that judgments of beauty are not cognitive or "logical" judgments, he criticizes the view that beauty is perfection known confusedly or indistinctly. Combining Kant's remark with Leibniz's view that beauty is--or, more precisely, flows from--perfection, we might conclude that Baumgarten simply lowered beauty from the level of distinct to that of confused concepts and tried to deduce its rules from the concept of perfection. If this was indeed Baumgarten's project, we might well ask to be excused from pursuing the subject further. (shrink)